Games that capture the feeling of isolation

[ghostxx]

Games like Deus Ex and the Thief games have always captivated me because of the feeling of isolation, of being one person against the world. I'm always a sucker for ducking through frigid New York apartments and dancing across city rooftops in a hostile, unforgiving environment.
Other games that give me this feeling are games like GTAIII and GTAIV, Gloomwood, the Dishonored games, BioShock, VTMB, etc.
With that in mind, got any recs? Thanks!