Best way to look for flights and hotels?

[Slaiji]

I know we've all read articles or heard from a friend the best way to find the cheapest flights on hotels are on like Tuesday night, vpn, incognito, etc...
I was wondering if anybody has the best set up in searching up the cheapest flight? As I get older, I have been taking the responsibility of purchasing my parent's flights so I would like best way to save money on this side of our lives.